Histo morphological changes in gall bladder mucosa associated with gall stones

Background and Aims: Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. In present study, we aimed find correlation between various gallstone characteristics (i.e., number, size, morphological type) with type of mucosal response mucosa inflammation, hyperplasia, metaplasia, carcinoma). Methods: The study was conducted prospectively on 250 patients undergoing cholecystectomy for symptomatic cholecystitis. Gallstones were assessed parameters, i.e., type. Gallbladder subjected examination. Sections taken from body, fundus, neck gallbladder. Results: Of cases, maximum mixed stones (54%) multiple number (46%). However, are non-significant variables precancerous lesions hyperplasia metaplasia). Statistically significant results obtained while comparing size (P = 0.012). Conclusion: As increases, cholecystitis, metaplasia carcinoma. Gallstone nonsignificant lesions.